English Course · C3-EN · Negida Academy
Sample Size Calculation in Clinical Research
Plan how many participants your study needs, design by design, and write the sample size paragraph for your protocol and paper.
Taught in English · ★ 4.4/5 on Trustpilot (227 reviews) · More than 40,000 trainees
Why this course matters
A study that is too small cannot answer its question.
Reviewers, ethics committees and funders all ask how you chose your number. This course answers what every researcher needs to know:
- Why does a study need a planned sample size?
- What do power, alpha and effect size mean?
- Where does the expected effect size come from?
- How do I write the sample size paragraph?
You calculate the number design by design, using free tools.
See the curriculumCourse overview
What you'll learn
A Start Here module, then five teaching modules. Each one answers one question.
Why do we study a sample?
Target and accessible populations, what makes a good sample, and the sampling methods.
What do you need before you calculate?
Power, alpha and why it is not the margin of error, and where the effect size comes from.
How do you calculate for an observational study?
Prevalence surveys, cohort and case-control studies, matched designs and correlation studies.
How do you calculate for a clinical trial?
Superiority, time-to-event, non-inferiority and equivalence trials, and the minimum clinically important difference.
How do you adjust and report the number?
Dropouts, cluster sampling, several outcomes, the paragraph for every design, a cheat sheet and practice cases.
The result
You will be able to justify your sample size
You will know which numbers go into the calculation, where they come from, and how to report them.
What you'll be able to do
- Choose and describe a sampling method
- Define effect size, alpha, beta and power
- Calculate the sample size for surveys, cohort, case-control and correlation studies
- Calculate it for superiority, non-inferiority and equivalence trials
- Write the sample size paragraph for your protocol and paper
What's included
- 16 video lessons, 2.5 hours
- 14 reading pages, including a cheat sheet and practice cases with answers
- 5 quizzes
- A guide to the free software and calculators
Your instructor
Dr. Ahmed Negida, MBBCh, PhD
Founder and Academic Advisor, Negida Academy
Dr. Negida is a translational research scientist in the USA and a research educator with 150+ scientific publications. Negida Academy is a US-based research organization and the most reputable clinical research training in MENA since 2014, with more than 40,000 trainees. Graduates work at top US institutions and were mentored to first-authored papers.
LEARN → APPLY → PUBLISH
Enroll
Plan your next study with confidence
One payment. Instant access. Everything is recorded, so you study at your own pace.
C3-EN: Sample Size Calculation in Clinical Research
$50
One-time payment
- 16 video lessons, 2.5 hours
- 14 reading pages and 5 quizzes
- Cheat sheet and practice cases with answers
- Taught in English
Want all five English courses? Get the bundle for $199 and save $76.
Other questions before you enroll? Contact the team.
Enrollment does not guarantee publication. Read the full disclosure.
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